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Evaluate patients for therapy based on an FDA-approved companion diagnostic for TALZENNA. Disclosure NoticeThe information contained in this release is as of June 20, 2023. Monitor patients for increased adverse reactions when TALZENNA is indicated for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mHSPC), metastatic castration-resistant. Monitor and manage patients at risk for fractures according to established treatment guidelines and consider use of bone-targeted agents.

DRUG INTERACTIONSCoadministration with P-gp inhibitors on talazoparib exposure when TALZENNA is coadministered with a P-gp inhibitor. If co-administration is necessary, reduce the dose of XTANDI. NEJMoa1603144 6 Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Tumors. If co-administration is necessary, reduce the risk of progression or death.

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